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HHS Public AccessAuthor manuscriptBioorg Med Chem Lett. Author manuscript; readily available in PMC 2017 April 01.Published in final edited kind as: Bioorg Med Chem Lett. 2016 April 1; 26(7): 1745749. doi:ten.1016/j.bmcl.2016.02.047.Author Manuscript Author Manuscript Author Manuscript Author ManuscriptCarbon nanodots as molecular scaffolds for development of antimicrobial agentsMaria Ngu-Schwemleina,*, Suk Entertaining Chinb, Ryan Hilemana, Chris Drozdowskia, Clint Upchurcha, and April HargroveaaDepartment bDepartmentof Chemistry, Winston-Salem State University, Winston-Salem, NC 27110, USA of Chemistry, Universiti Malaysia Sarawak, 94300 Kota Samarahan, Sarawak,MalaysiaAbstractWe report the prospective of carbon nanodots (CNDs) as a molecular scaffold for enhancing the antimicrobial activities of compact dendritic poly(amidoamines) (PAMAM). Carbon nanodots ready from sago starch are readily functionalized with PAMAM by using N-ethyl-N-(3dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS).1227489-83-9 custom synthesis Electron microscopy images of those polyaminated CNDs show that they are approximately 300 nm in diameter.PMID:24078122 Infrared and fluorescence spectroscopy analyses from the water-soluble material established the presence on the polyamidoaminated moiety and also the intrinsic fluorescence of your nanodots. The polyaminated nanodots (CND-PAM1 and CND-PAM2) exhibit in vitro antimicrobial properties, not just to nonmultidrug resistant bacteria but also towards the corresponding Gram-negative multidrug bacteria. Their minimum inhibitory concentration (MIC) ranges from 8 to 64 /mL, that is much reduced than that of PAMAM G1 or the non-active PAMAM G0 and CNDs. Also, they show synergistic impact in mixture with tetracycline or colistin. These preliminary outcomes imply that CNDs can serve as a promising scaffold for facilitating the rational style of antimicrobial supplies for.